UPenn Brain Bank
: Proteomic data collected from DLPFC
Mt Sinai Mouse Model
: RNA sequencing data generated from entorhinal cortex and dentate gyrus from APP and PSEN mouse models.
Mt Sinai Drosophila Model
: Raw data from RNA sequencing of transgenic fly lines previously released.
Lilly Primary Microglia
: RNA sequencing data from microglia isolated from rTg4510 tau mouse model.
August 28 2015
Mt Sinai Brain Bank RNA sequencing study Whole exome sequencing on all individuals as well as additional RNA sequencing from additional samples
Baltimore Longitudinal Study of Aging: Proteomic data from precuneus homogenate
Mayo Clinic LOAD Risk Case Control Association Study: Genotypes for protein altering variants in TLR4 and TLR5
Mt Sinai Brian Bank Expression Array Study: CEL files are now available.
>Mt Sinai Drosophila Model: RNA sequencing data generated from single, double, and triple transgenic fly lines for TREM2, TYROBP, and AB42.
May 28 2015
ROS/MAP: RNA sequencing data generated from prefrontal cortex.
Baltimore Longitudinal Study of Aging: Proteomic data
Mayo Clinic Brain Expression Studies: RNAseq data generated from temporal cortex
Monocyte-derived microglia cells: RNAseq data generated from MDMi
APP and Tau Mouse Models: RNA sequencing data generated from two APP mouse models.
iPSC Model: RNA sequencing data generated from iPSC-derived neural progenitor cells and mature neurons. Astrocytes isolated from human brain.
ROS/MAP: Expression array and miRNA data derived from frontal cortex
Harvard Brain Bank: Imputed genotype data
March 3 2015
This release was largely comprised of existing, pre-award data from human samples that was used in generating preliminary results on the grant applications of the U01 AMP-AD projects. Study descriptions are provided in detail in The AMP-AD Data section. These include:
Mt Sinai Brian Bank RNAseq Study: RNA sequencing and clinical data generated from 3 brain regions of human postmortem brain samples collected from AD and control individuals.
APP and Tau Mouse Models: RNA sequencing data generated from two Tau mouse models.
ROS/MAP: DNA methylation, genotype, clinical data
Mt Sinai Brain Bank Expression Array Study: expression array, clinical data and co-expression networks
Mayo Clinic LOAD Risk Case Control Association Study: genotype, covariate data
Mayo Clinic Brain Expression Studies: expression array, RNA sequencing, and covariate data (with genotypes available for these samples within the Mayo Association Study)
Emory ADRC Brain Bank: pooled proteomic data
Harvard Brain Bank: expression array, genotype, and covariate data
Mt Sinai Brian Bank Expression Array Study: Coexpression networks
Mayo Clinic Brain Expression Study: eGWAS results using expression arrays