The 26.8 Data Release includes updates to the Brain_CASCADE_CAA and ROSMAP studies.

Proper acknowledgment of data sources is not only mandatory for users of the AD Knowledge Portal, it also enhances the visibility of your work and elevates recognition of datasets used. All data use must be acknowledged with the following: the AD Knowledge Portal Acknowledgement Statement; and an Acknowledgement Statement specific to the study/dataset used, from the relevant Study page; and a Data Availability statement that includes a direct link to access relevant resources, known as a dataset DOI. For more information and pre-written acknowledgement statements, see Data Use & Acknowledgement.

Human

  • The Brain_CASCADE_CAA Study

    The Brain CASCADE Cerebral Amyloid Angiopathy Study (Brain_CASCADE_CAA) is part of the BRAIN-CASCADE U19 program, which aims to characterize the spatial distribution of cellular signatures in tissue from individuals across age and brain pathologies. Based on a combination of multiplexed antibody staining and highly multiplexed in situ hybridization, this study aims to localize cell types with respect to age and pathological inclusions across individuals from the ROSMAP cohort.

    • This data release provides Xenium spatial transcriptomics data from the calcarine cortex of 95 Religious Orders Study and Memory and Aging Project (ROSMAP) Study participants using a custom 480-gene panel.

  • The ROSMAP Study

    The ROSMAP Study provides genomics, transcriptomic, epigenetic, proteomic, and metabolomic data on individuals as part of the Religious Orders Study (ROS) and the Memory and Aging Project (MAP) enrolled by the Rush Alzheimer’s Disease Center.

    • This data release provides proteomics and phosphoproteomics data of dorsolateral prefrontal cortex samples from 192 ROSMAP participants.