The 26.2 Data Release provides updates to human studies, including the AGMP POINTER Microbiome Ancillary and AMP-AD Diverse Cohorts studies.

Proper acknowledgment of data sources is not only mandatory for users of the AD Knowledge Portal, it also enhances the visibility of your work and elevates recognition of datasets used. All data use must be acknowledged with the following: the AD Knowledge Portal Acknowledgement Statement; and an Acknowledgement Statement specific to the study/dataset used, from the relevant Study page; and a Data Availability statement that includes a direct link to access relevant resources, known as a dataset DOI. For more information and pre-written acknowledgement statements, see Data Use & Acknowledgement.

Human

  • mCITE-Seq Study developed a CITE-Seq (CITE = Cellular Indexing of transcriptomes and epitopes) panel for cell-surface proteome and transcriptome profiles of single human microglia. 

    • This release provides single cell gene expression, LC-MS, and flow cytometry files. For titration experiments of the candidate antibodies that were to be added to the panel , human peripheral blood mononuclear cells (PBMCs) and HMC3 microglia (immortalized human microglial cell line) were used. For validation experiments, different preparations of human iPSC-derived microglia (iMG), HMC3 microglia, PBMCs and microglia freshly isolated from surgical tissue or postmortem tissue were used.

  • Alzheimer Gut Microbiome Project (AGMP) POINTER Microbiome Ancillary Study comprises data from 802 participants, a self-selected sample from participants in the U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER). Plasma samples were provided as part of their participation in U.S. POINTER and were obtained from the POINTER biorepository at The Alzheimer’s Therapeutic Research Institute (ATRI) at the University of Southern California (USC) Keck School of Medicine.

    • This release provides metabolomics data from the study’s baseline plasma samples (N=802), including individual sample-level metabolomics measurements.

  • The ADKP Metadata Harmonization Study

    • This study release includes harmonized clinical metadata from multiple studies in the portal, including ROSMAP, MayoRNAseq, MSBB, AMP-AD Diverse Cohorts, SEA-AD, NPS-AD, and others. Common columns between studies (for example age, sex, CERAD, Braak stage) have been standardized to have the same column names and values across all studies to make cross-comparison and meta-analysis simpler.

  • The AMP-AD Diverse Cohorts Study

    • This release from the AMP-AD Diverse Cohorts studies includes processed single-cell ATACseq files, including fragment files and aggregate