The 25.6 Data Release includes updates to human studies, including ROSMAP and the WHICAP_Immunoprofiling Study.

Human

  • The MOA-PAD Study

    This study provides epigenetic data for Alzheimer’s disease and non-demented control dorsolateral prefrontal cortex brain samples from 223 donors, which were obtained from the University of Pittsburgh Alzheimer’s Disease Research Center (PITT-ADRC). 

    • This release provides 3 raw genotype data files of the PITT-ADRC cohort in Plink binary format.

  • The ROSMAP Study

    This study provides genomics, transcriptomic, epigenetic, proteomic, and metabolomic data on individuals as part of the Religious Orders Study (ROS) and the Memory and Aging Project (MAP) enrolled by the Rush Alzheimer’s Disease Center.

    • This release provides new T2T-aligned count matrices from 10x visium v2, and v3 sequencing generated from existing ROSMAP participants.

  • The WHICAP_Immunoprofiling Study

    This study generates cytometric data and bulk RNAseq profiles of peripheral blood mononuclear cells (PBMC) from older individuals.

    • This release provides additional flow cytometry data for peripheral blood mononuclear cells sourced from additional individuals to the initial 319, as well as updated clinical metadata for all individuals and biospecimens.

  • The SEA-AD Integrative Analysis Center study (SEA-AD IAC)

    This study is part of the Community Data Contribution Program (CDCP) and includes data generated by the Seattle Alzheimer’s Disease Brain Cell Atlas (SEA-AD) Integrative Analysis Center (IAC).

    • This release provides re-processed both SEA-AD and non-SEA-AD generated data, including snRNAseq and multiomics data. 

  • The AGMP BEAM Study

    This study generates lipidomics, targeted and untargeted metabolomics and metagenomics for 17 individuals, cognitively normal or diagnosed with MCI.

    • This release provides Baker lipidomics and Nightingale NMR metabolomics from serum and CSF, UCSD untargeted metabolomics from serum, plasma and fecal samples, as well as metadata for all individuals and biospecimens.