The 24.10 Data Release includes updates to model studies.
Models
The BCM-DMAS Study
The BCM-DMAS Study uses fruit fly models (Drosophila melanogaster) to dissect gene expression changes associated with neurodegenerative disease triggers (Alzheimer’s, Parkinson’s, and Huntington’s diseases) and their interactions with aging.
- This release provides RNA sequencing data from UAS-VGlut fruit flies and single cell RNA sequencing data
The NPS-AD Study
This study provides single-nucleus RNAseq profiles from the dorsolateral prefrontal cortex of 1494 donors from the Mt Sinai Brain Bank, NIMH Human Brain Collection Core, and ROSMAP cohorts. In addition to Alzheimer’s Disease status, information on the presence of other dementias or neuropsychiatric conditions is also provided.
- This release includes an additional metadata file adding one csv table mapping between individualID and DonorID used in the The Mount Sinai Neuropsychiatric Symptoms in AD (NPS-AD) Study.
The Jax.IU.Pitt_LOAD1.Diet study
This study examines how a high-fat diet (HFD) influences genetically modified mice that model Alzheimer’s Disease. Mice with specific Alzheimer’s-related genes (LOAD1.Plcg2M28L) were studied at Indiana University (IU), while others (LOAD1.Mthfr677C>T) were studied at JAX labs. Each experimental group was paired with LOAD1 control mice for comparison, with additional B6 mice as strain controls at IU. Both IU and JAX bred these mice to produce groups with three matching Alzheimer’s-related genes, enabling a more detailed analysis of HFD’s effects on disease progression.