The 20.7 Data Release provides bulk brain RNAseq data aligned using the MAP-Rseq pipeline from the MayoRNASeq study, including additional samples from donors progressive supranuclear palsy; and RNAseq sample exchange data from the AMP-AD Diverse Cohorts study.

Human

  • The AMP-AD_DiverseCohorts Study

    The AMP-AD Diverse Cohorts Study is a cross-consortium project generating harmonized datasets from diverse human cohorts. This study provides post-mortem whole genome sequencing and brain bulk RNA sequencing data from over 800 individuals, including 288 Black or African American individuals and 277 Hispanic or Latino individuals representing the spectrum of Alzheimer’s Disease phenotypes. Data is generated from research teams at Rush University, Emory University, the Mayo Clinic, Columbia University, and Mt Sinai Medical School.

    • This release provides raw data from RNAseq sample exchanges conducted in order to control for batch effects between sequencing centers. 

  • The MayoRNAseq Study

    This study contains data from brain tissue from individuals with neuropathological diagnosis of Alzheimer’s disease, progressive supranuclear palsy, pathologic aging, or elderly controls  without neurodegenerative diseases obtained from the Banner Sun Health Research Institute and the Mayo Clinic Brain Bank. Previously released from this study is RNAseq on bulk tissue from the temporal cortex and cerebellum, proteomics from the temporal cortex and GWAS and whole genome sequencing. This release adds:

    • Bam files with data from existing temporal cortex and cerebellum specimens aligned using the Mayo Analysis Pipeline for RNA Sequencing (MAP-RSeq)
    • RNAseq data from additional samples with progressive supranuclear palsy, as part of the Pathological Aging subset