The 18.2 Data Release includes new human studies and deep phenotyping data from the 5XFAD mouse model.

Human

  • The HBI_scRNAseq Study 

    This study provides scRNA sequencing 10x Cellranger counts for 33 blood and brain samples for patients across several neurological diseases.

  • The DukeAD_PTSD Study 

    This study presents the results of a genome-wide pleiotropy analysis of Alzheimer’s disease and post-traumatic stress disorder, including conditional false-discovery rates for SNPs identified in GWAS of Alzheimer’s disease and PTSD. 

  • The ROSMAP Study

    This study contains data generated from subjects participating in the Religious Orders Study (ROS) and Memory and Aging Project (MAP). These are longitudinal clinical-pathologic cohort studies of aging and AD run from Rush University. Previously released from these studies is GWAS, WGS, RNAseq on bulk and single nuclei from the dorsolateral prefrontal cortex, microglia RNAseq, array mRNA and miRNA expression, epigenetics, and metabolomics.

    • This release adds:
      • Protein quantitative trait loci (pQTL) results generated on data from the ROSMAP and Banner studies as described in Genetic control of the human brain proteome
      • Updated metadata files for clarity and cohesion.
      • Deprecated ChIPseq, arrayMethylation, and arraymiRNA covariate files. This data is now contained within the new and updated metadata files.

  • The MSBB Study

    This study provides WES, WGS, RNAseq,  label free, and Tandem Mass Tag proteomics on a cohort from the Mount Sinai Brain Bank.

    • The release adds:
      • Normalized TMT proteomics data

  • The ROSMAP_CognitiveResilience Study

    This study provides bulk brain RNAseq data from Brodmann Areas 6 and 37 of individuals from two longitudinal studies of aging – the Religious Orders Study and the Memory and Aging Project (ROSMAP). Included are ROSMAP individuals who came to autopsy without dementia, but with high levels of Alzheimer’s disease pathology. A future release will include Proteomics and 3D dendritic spine morphometry on these individuals.

Models

  • The UCI_5XFAD Study 

    This study provides deep phenotyping data from the 5XFAD mouse model

    • This updates the individual metadata file with information on a set of mice used in the immunoassays that were missing.

  • The sRNAseq_microglia_wild_ADmice Study

    This study provides scRNA-seq of microglia from 29 brain samples from C57BL/6J (B6) and wild-derived strains (WSB/EiJ, CAST/EiJ and PWK/PhJ) of mice with and without APP/PS1. It also includes a Shiny app that allows users to query the microglia expressed genes identified in this study.