The 18.11 Data Release includes human data and tools for drug development.
Human
The ROSMAP_Lipidomics_Emory Study
This study provides lipidomics data on human pre-mortem plasma samples (n = 674) and post-mortem brain tissue (n = 384) from Religious Order Study (ROS)/Memory and Aging Project (MAP) participants.
The VirusResilience_Mayo.MSBB.ROSMAP Study
This study provides uniformly processed mitochondrial genome variant calls based on whole genome sequencing data from 1881 individuals profiled through the ROSMAP, MSBB, and MayoRNAseq studies.
The ROSMAP Study
This study provides genomics, transcriptomic, epigenetic, proteomic, and metabolomic data on individuals as part of the Religious Orders Study (ROS) and the Memory and Aging Project (MAP) enrolled by the Rush Alzheimer’s Disease Center.
- This release adds RNAseq TPM and count data associated with age- and sex-normalized residuals generated from previous sequencing data from multiple brain regions.
Tools
ChemMine Tools is a free online service for analyzing and clustering small molecules by structural similarities, physicochemical properties or custom data types.
This Bioconductor cheminformatics package for analyzing drug-like small molecule data in R. Its latest version contains functions for efficient processing of large numbers of small molecules, physicochemical/structural property predictions, structural similarity searching, classification and clustering of compound libraries with a wide spectrum of algorithms.
This is an Bioconductor package that integrates a suite of existing and novel algorithms into an analysis environment for gene expression signature (GES) searching combined with functional enrichment analysis (FEA) and visualization methods to facilitate the interpretation of the search results.
This Bioconductor package provides utilities for identifying drug-target interactions for sets of small molecule and/or gene/protein identifiers
This Bioconductor package serves as a query interface for important community collections of small molecules, while also allowing users to include custom compound collections.
Acknowledgment statement updates
As a reminder, any use of AD Knowledge Portal data or resources must acknowledge and cite both the AD Knowledge Portal and the data contributor(s). Note that the following metabolomics data has an updated acknowledgement statement that includes an attribution of the Alzheimer’s Disease Metabolomics Consortium (ADMC): The ROSMAP study, the ADMC_ADNI1 Study, the ADMC_ADNI2-GO Study, the ADMC_UPenn Study, the Jax.IU.Pitt.Proteomics_Metabolomics_Pilot Study, the ADMC_ADNI_BakerLipidomics Study, the ADMC_ADNI_NightingaleNMR Study.