The July 2020 Data Release includes a new study of miR155 deletion, data from the AD-BXD study, and additional data from two human cohorts.
Human
The snRNAseqAD_TREM2 Study
This study provides single nuclei RNAseq from the dorsolateral prefrontal cortex as described in Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease using 32 specimens from the ROSMAP study.This release adds:
Cell clustering analyses.The MayoRNAseq Study
This study contains data from brain tissue from individuals with neuropathological diagnosis of Alzheimer’s disease, progressive supranuclear palsy, pathologic aging, or elderly controls without neurodegenerative diseases obtained from the Banner Sun Health Research Institute and the Mayo Clinic Brain Bank. Previously released from this study is RNAseq on bulk tissue from the temporal cortex and cerebellum, proteomics from the temporal cortex and GWAS and whole genome sequencing.This release adds:
A new RNA seq counts file for the temporal cortex data, a marker file, and scripts to do the analysis described in Deciphering cellular transcriptional alterations in Alzheimer’s disease brains. The analysis for this paper uses data from multiple AMP-AD studies.
Models
AD-BXD study: This study provides immunohistochemistry, behavioural data, and RNAseq on a genetically diverse mouse model. The RNAseq data was previously indexed from SRA. These links have been deprecated by NCBI. To access the RNAseq data go directly to GEO Series GSE101144.
miR155 Study: This is a new study with data as described in miR155 regulation of behavior, neuropathology, and cortical transcriptomics in Alzheimer’s disease. The data consists of RNAseq generated from the prefrontal cortex of 48 mice from an APP/SEN1 mouse model in the presence or absence of miR155.
Tools
This release adds an updated version of the tools section in the portal. Computational and Experimental tools are now under separate tabs. The Experimental tools include an updated set of Mouse Models created through the MODEL-AD program. Click on the title of the tool card for detailed information about the model through The Jackson Laboratory, and note links to studies where data has been generated on a model.