This study contains data generated from subjects participating in the Religious Orders Study (ROS) and Memory and Aging Project (MAP). These are longitudinal clinical-pathologic cohort studies of aging and AD run from Rush University. Previously released from these studies is GWAS, WGS, RNAseq on bulk and single nuclei from the dorsolateral prefrontal cortex, microglia RNAseq, array mRNA and miRNA expression, epigenetics, and metabolomics.
This release adds:
- RNAseq from 13 samples of Microglia single cells isolated from the dorsolateral prefrontal cortex from 13 individuals with mild cognitive impairment and Alzheimer’s disease.
This release modifies:
- Single nucleus RNAseq entities and file handles were renamed so that the entity name and file handle matches for each file.
- 24 single nucleus RNAseq files were submitted in duplicate. The duplicate files were moved to a Deprecated data folder. Eight duplicate specimenID records were removed from the biospecimen metadata file and scRNAseq assay metadata file. In both metadata files, the contents of the two records were condensed to retain all available metadata.