December 2019 Data Release Updates include modifications to the ROSMAP study, label free proteomics from the UPP study, QC assessment of WGS data from the MayoRNAseq study, and additional GWAS files the MC-CAA study.

Human

  • ROSMAP study

    This study contains data generated from subjects participating in the Religious Orders Study (ROS) and Memory and Aging Project (MAP). These are longitudinal clinical-pathologic cohort studies of aging and AD run from Rush University. Previously released from these studies is GWAS, WGS, RNAseq on bulk and single nuclei from the dorsolateral prefrontal cortex, microglia RNAseq, array mRNA and miRNA expression, epigenetics, and metabolomics.

    This release adds:

    • RNAseq from 13 samples of Microglia single cells isolated from the dorsolateral prefrontal cortex from 13 individuals with mild cognitive impairment and Alzheimer’s disease.

    This release modifies:

    • Single nucleus RNAseq entities and file handles were renamed so that the entity name and file handle matches for each file.
    • 24 single nucleus RNAseq files were submitted in duplicate. The duplicate files were moved to a Deprecated data folder. Eight duplicate specimenID records were removed from the biospecimen metadata file and scRNAseq assay metadata file. In both metadata files, the contents of the two records were condensed to retain all available metadata.

  • MayoRNAseq study

    This study contains data from brain tissue from individuals with neuropathological diagnosis of Alzheimer’s disease, progressive supranuclear palsy, pathologic aging, or elderly controls  without neurodegenerative diseases obtained from the Banner Sun Health Research Institute and the Mayo Clinic Brain Bank. Previously released from this study is RNAseq on bulk tissue from the temporal cortex and cerebellum, proteomics from the temporal cortex and GWAS and whole genome sequencing.

    This release adds:

    • Quality control assessment of the whole genome sequencing data.

  • MC-CAA study

    This is two studies focused on cerebral amyloid angiopathy (CAA), utilizing post-mortem tissue samples from individuals neuropathologically diagnosed with Alzheimer’s disease. Previously released is RNAseq on bulk tissue from the temporal cortex from ‘study 2.’

    This release adds:

    • Raw and normalized gene counts from the cerebellum from ‘study 1’ . Raw data for study 1 will be provided at an upcoming data release. Also provided is GWAS plink files for individuals in study 1. The metadata files for this study have been updated.

Models