The November 2018 Data Release includes additional Data for ROSMAP and MayoRNAseq, plus a new human study of 470 individuals and a model study from the Jackson Laboratory. Data Updates to MSBB, Banner, and Emory studies.
Targeted proteomics by Selected Reaction Monitoring (SRM). A new version of the SRM data matrix file (syn10468857) adds protein measures on the DLPFC from an additional 385 individuals, resulting in the measure of 67 proteins on 1226 individuals. This set has been termed Round 1. A new set of 119 protein measures on the DLPFC has been generated in Round 2* on 1227 individuals. The assay description has been updated to reflect the difference in protocols between Round 1 and Round 2. Single-nucleus RNA-sequencing. Raw data has been provided from sequencing of single nuclei isolated from the DLPFC of 8 individuals ChIPSeq. Processed data including H3K9ac peaks and read counts has been provided for 669 samples that passed quality control and had complete pathologic characterization.
The ADMC_ADNI2-GO study. This includes Bile Acids and metabolomics data on the p180 platform across 470 individuals from the ADNI cohort. Data is stored on the ADNI website within the Laboratory of Neuro Imaging (LONI). ADNI has additional data access requirements. Researchers interested in ADNI data should apply for data access through LONI.
New Model Study
The AD Cross Species study: This study examines the overlaps between gene expression changes in human AD brains and those from mouse models AD or other models relevant to neurodegenerative diseases. 30 AD-associated gene coexpression modules were examined for overlap with 234 curated differentially-expressed gene sets from mouse brain RNA-sequencing experiments, reprocessed from 99 studies total (GEO and AMP-AD Knowledge Portal). Processed data from all studies and analysis results are provided.