The 24.9 Data Release includes data from additional donors in the Diverse Cohorts study, gene expression data from the ROSMAP-IA study, and RNA sequencing data from the UCI_Trem2-R47H_NSS Study.

Human

  • The AMP-AD_DiverseCohorts Study

    The AMP-AD Diverse Cohorts Study is a cross-consortium project generating harmonized datasets from diverse human cohorts. This study provides post-mortem multi-omic data from over 850 individuals, including 305 Black or African American individuals and 336 Hispanic or Latino individuals representing the spectrum of Alzheimer’s Disease phenotypes. Data is generated from research teams at Rush University, Emory University, the Mayo Clinic, Columbia University, and Mt Sinai Medical School.

    • This release provides raw and processed data from an additional 135 WGS  samples from donors in the Rush ADRC cohorts.

  • The ROSMAP-IA Study 

    This study explores genetic contributions to molecular pathways affecting AD risk and resilience. This release provides gene expression data for iPSCs sourced from 44 autopsied individuals in the ROS and MAP cohorts using RNA sequencing and tandem mass tag-mass spectrometry.

Models

  • The UCI_Trem2-R47H_NSS Study

    This study provides RNA-seq, immunohistochemistry, plasma neurofilament light chain (NfL), and biochemistry data for the Trem2em1Aduci allele. The Trem2em1Aduci allele models a mutation in the triggering receptor on myeloid cells 2 (Trem2) gene. This mutation (R47H) matches one in humans that is linked to late-onset Alzheimer’s Disease. RNA-seq analysis of the hippocampus shows that the Trem2em1Aduci allele is expressed at levels similar to the wild-type Trem2, with no cryptic splicing from the mutant allele.

    • This release includes processed RNA sequencing data.