The 19.1 Data Release includes methylation array data from APOEe4-carrying ROSMAP donors in the RR_APOE4 Study, raw gene counts from harmonized ROSMAP, MSBB, and Mayo RNAseq data aligned to the GRCh38 reference genome as part of the RNAseq_Harmonization Study, and mouse electrophysiology data from the UCI_3xTg-AD Study.

Human

  • The RNAseq_Harmonization Study

    This study is a release of RNA sequencing data from the ROSMAP, MSBB, and MayoRNAseq studies that has been processed using a common workflow. The study is an extension of the rnaSeqReprocessing study, but uses the GRCh38 reference genome for sequence alignment.

    • This release provides harmonized raw gene counts for the Mayo, ROSMAP, and MSBB cohorts
    • A future release will provide updated normalized gene counts and differential expression results

  • The RR_APOE4 Study

    This study provides methylation array data from brain tissue belonging to 349 donors selected from the Religious Orders Study (ROS) and Memory and Aging Project (MAP) cohorts. The individuals included in this study represent the full spectrum of Alzheimer’s disease severity, but were selected in a manner designed to enrich the proportion of APOE e4 carrying individuals (65%, n = 226). 

    • This release provides raw and processed data generated from the Illumina MethylationEPIC array.

Models

  • The UCI_3xTg-AD Study

    This study provides transcriptomic data from the hippocampus and cortex of mice expressing three mutations of APP, MAPT, and PSEN1. This release provides:

    • Updated individual and biospecimen metadata with corrected identifiers for one mislabeled mouse and associated biospecimens
    • Electrophysiology (LTP) data 
    • Updated immunoassay (Immunofluorescence) data with all individual mouse-level observations for each stain reformatted into one file

  • The UCI_5XFAD Study

    This is a study of a familial Alzheimer’s disease mouse model expressing mutant human APP and PS1. 

    • This release provides corrected individual metadata data that includes previously-missing values

  • The Jax.IU.Pitt_5XFAD Study

    This is a study of a familial Alzheimer’s disease model expressing mutant human APP and PS1. 

    • This release provides updated individual metadata with corrected genotype values

Tools

  • Aging-PheWAS
    The Aging-PheWAS viewer enables users to explore genetically predicted tissue-specific gene expression associations with a collection of aging-related traits and outcomes.