January 2018
- Jointly called WGS data from the MSBB study, the MayoRNAseq study, and the ROSMAP are now available. Data released in November 2017 was variants called within each study.
The following new studies, additional data for existing studies, and analysis results have been provided with this release. - The TyrobpKO_AppPs1 study. RNAseq from mice with one or both copies of the Tyrobp gene knocked-out crossed with APP/PS1 Jax mice to obtain different combination of the Tyrobp and AppPS1 genotypes. This complements RNAseq data released previously from the TyrobpKO study.
- The iPSCAstrocytes study. RNAseq from astrocytes differentiated from human induced pluripotent stem cells. This complements RNAseq data released previously from the iPSCMicroglia study.
The EmoryDrosophilaTau model study. This study has previously released proteomics data. This release provides RNAseq from the same samples.
- The CHDWB. A mapping file between the cognitive and clinical assessments, and metabolomics data and gene expression data available in GEO.
The TAUAPPms model study. Protein validation of Abi3 and PLCG2 in the app model.
- The ROSMAP WGS data: 16 samples were identified that are either sex mismatches or discordant with previous array-based genotype data and recommended to be excluded. Samples are listed in WGS_sample_QC_info. Additional QC files can be found in the QC files
The MSBB study: 55 RNAseq, 8 WES, 15 WGS samples are recommended to be excluded or remapped to the correct donor. Samples are listed in MSBB_RNAseq.WES.WGS_sample_QC_info
March/April 2018
- April 2018 – Data Release | Additional Data for Previously Released Study
The SUNYStrokeModel. Includes electrophysiological and behavioral data (Active Place Avoidance, Novel Object Recognition) in the following models: C57BL/6J – (WT), BKS.Cg-Dock7m+/+Leprdb/J, APP/PS1, J20, a/a Dock 7m+/Dock7m+, a/a Dock7m+/+Leprdb, where mice have been tested at 5 mo after a stroke or sham transient middle cerebral artery occlusion (tMCAo) procedure
March 2018 – Data Release | Additional Data for Previously Released Study
The ROSMAP study. Metabolomics data from brain and serum. IncludesBile Acids and the AbsoluteIDQ p180 assay
February 2018
- February 2018 – Data Release #2 | New Human Study
The DiCAD study (Interdisciplinary Research to Understand the Interplay of Diabetes, Cerebrovascular disease and Alzheimer’s disease): A study of 200 community dwelling late middle-aged Hispanics without dementia from Northern Manhattan. Includes a questionnaires of general health, neuropsychological testing, fasting phlebotomy and oral glucose tolerance testing, brain Magnetic Resonance Imaging (MRI), and Brain Amyloid Positron Emission Tomography (PET).
February 2018 – Data Release | Additional Data for Previously Released Study
The TAUAPPms study. Custom-designed Nanostring chips were used to validate retained intron events in 12- and 20 month old CRND8 transgenic and non-transgenic mice. See probeset details and data
February 2018 – Data Update
The ROSMAP WGS set was missing clinical data from some individuals. The ROSMAP clinical file has been updated. Please download a new version